Clozapine, agranulocytosis, and benign ethnic neutropenia

Clozapine, agranulocytosis, and benign ethnic neutropenia.

C lozapine is an atypical antipsychotic that is effective in treatment resistant schizophrenia. The National Institute for Health and Clinical Excellence (NICE) guidelines for schizophrenia specify that ‘‘in individuals with evidence of treatment resistant schizophrenia, clozapine should be introduced at the earliest opportunity’’. A severe adverse effect of clozapine that limits its more wides...

Agranulocytosis during Clozapine Therapy

Sir, This is in response to the article' Do Indian researchers read Indian research? a reappraisal, four years later', published in April 2000 (No.2, f Vol.42) issue of your journal. The authors of this article have documented their observations on my article 'Transsexualism in Schizophrenia : a case report' (April, 1998, Vol.40, No.2) that I did not refer to their article, 'Behaviour Therapy f...

Tumor necrosis factor constellation polymorphism and clozapine-induced agranulocytosis in two different ethnic groups.

Genes of the major histocompatibility complex (MHC) are associated with susceptibility to different immune and nonimmune mediated diseases. We had reported that the drug adverse reaction, clozapine-induced agranulocytosis (CA), is associated with different HLA types and HSP70 variants in Ashkenazi Jewish and non-Jewish patients, suggesting that a gene within the MHC region is associated with CA...

Biological mechanisms behind clozapine-induced agranulocytosis

HLA associations in clozapine-induced agranulocytosis.

We previously reported preliminary results of association of clozapine-induced agranulocytosis (CA) with HLA-B38, DR4, DQ3 in five Ashkenazi Jewish patients and with HLA-DR2, DQ1 in four non-Jewish patients. In the present study, 31 additional patients with CA, 10 Ashkenazi Jewish, and 21 of non-Jewish ancestry, were studied. HLA alleles and haplotypes were compared among 52 patients (33 Ashken...